Kierownik zespołu
Dr hab. Marcin Górecki, prof. IChO PAN

Grant Narodowego Centrum Nauki (NCN) SONATA nr 2019/35/D/ST4/00394 pt. ”Spektroskopie dichroizmu kołowego (CD) w fazie stałej jako narzędzia wspierające rozwój chemii medycznej”

Grant obliczeniowy Wrocławskiego Centrum Sieciowo-Superkomputerowego (WCSS)


K. Olszewska, A. Mizera, P. Ławniczak, A. Kamińska, R. Santillan, M. Morales-Chamorro, E. Ochoa, N. Farfán, A. Łapiński, M. Górecki, I. Jastrzebska, T. Runka, „Molecular Dynamics of Steroidal Rotors Probed by Theoretical, Spectroscopic and Dielectric Methods”, Chem. Eur. J.

J. E. Rode, J. Wasilczenko, M. Górecki, „Differentiation of solvatomorphs of active pharmaceutical ingredients (API) by solid-state vibrational circular dichroism (VCD)”, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

N. Hachlica, A. Kolodziejczyk, M. Rawski, M. Górecki, A. Wajda, A. Kaczor, „“Nature or nurture” – how environmental factors influence the conformational memory of amyloid fibrils”, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Q. Zhong, V. Barát, D. Csókás, K. Niu, M. Górecki, A. Ghosh, J. Björk, D. Ebeling, L. Chi, A. Schirmeisen, M. C. Stuparu, „On-Surface Stereochemical Characterization of a Highly Curved Chiral Nanographene by Noncontact Atomic Force Microscopy and Scanning Tunneling Microscopy”, CCS Chem.

K. Nowak, O. Morawski, F. Zinna, G. Pescitelli, L. Di Bari, M. Górecki, M. Grzybowski, „Strong chiroptical effects in the absorption and emission of macrocycles based on the 2,5-diaminoterephthalate minimal fluorophore”, Chem. Eur. J.

N. Hachlica, M. Rawski, M. Górecki, A. Wajda, A. Kaczor, „Chiral and structural polymorphism of fibril architectures of homologous lysozymes”Chem. Eur. J.

M. Pollastrini, L. Pasquinelli, M. Górecki, F. Balzano, L. Cupellini, F. Lipparini, G. Uccello Barretta, F. Marchetti, G. Pescitelli, G. Angelici, „A Unique and Stable Polyproline I Helix Sorted out from Conformational Equilibrium by Solvent Polarity”, J. Org. Chem.

W. Depa, B. Bisek, M. Górecki, M. Michalak, „Epoxydibenzo[b,f][1,5]diazocines: from a hidden structural motif to the efficient solvent-free synthetic protocol”, Synthesis

G. Albano, M. Górecki, T. Jávorfi, R. Hussain, G. Siligardi, G. Pescitelli, L. Di Bari, „Spatially Resolved Chiroptical Study of Thin Films of Benzo[1,2-b:4,5-b’]dithiophene-based Oligothiophenes by Synchrotron Radiation Electronic Circular Dichroism Imaging (SR-ECDi) Technique”, Aggregate

M. Górecki , J. Frelek, „A Holistic Approach to Determining Stereochemistry of Potential Pharmaceuticals by Circular Dichroism with β-Lactams as Test Cases”, Int. J. Mol. Sci.

M. Górecki, F. Lipparini, G. Albano, T. Jávorfi, R. Hussain, G. Siligardi, G. Pescitelli, L. Di Bari, „Electronic Circular Dichroism Imaging (CDi) casts a new light on the origin of solid-state chiroptical properties”, Chem. Eur. J.

D. Ghosh, M. Górecki, G. Pescitelli, K. Kumar Damodaran, „Enantioselective Gel Phase Synthesis of Metal-Organic Materials”, Angew. Chem. Int. Ed.

M. Górecki, M. Enamullah, M. Ariful Islam, M. Khairul Islam, S. P. Höfert, D. Woschko, C. Janiak, G. Pescitelli, “Syntheses and characterizations of bis[(R- or S)-N-1-(X-C6H4)ethyl-2-oxo-1-naphthaldiminato-K2N,O]-Λ/Δ-cobalt(II) (X = H, p-OCH3, p-Br) with symmetry- and distance-dependent VCD enhancement and sign inversion”, Inorg. Chem.

M. Górecki, J. Frelek, „Towards seeking the right chiroptical tool to assign the stereochemistry of bioactive compounds: effectiveness, challenges, and perspectives”, TrAC – Trends Anal. Chem.

M. Michalak, B. Bisek, M. Nowacki, M. Górecki, „Base-Catalyzed, Solvent-Free Synthesis of Rigid V-Shaped Epoxydibenzo[b,f][1,5]diazocines”, J. Org. Chem

Ł. Szyszka, M. Górecki, P. Cmoch, S. Jarosz, “Fluorescent Molecular Cages with Sucrose and Cyclotriveratrylene Units for the Selective Recognition of Choline and Acetylcholine”, J. Org. Chem.

Ł. Szyszka, P. Cmoch, M. Górecki, M. Ceborska, M. A. Potopnyk, S. Jarosz, “Chiral molecular cages based on cyclotriveratrylene and sucrose units connected with p-phenylene linkers”, Eur. J. Org. Chem.

V. Zullo, M. Górecki, L. Guazzelli, A. Mezzetta, G. Pescitelli, A. Iuliano, “Exploiting isohexide scaffolds for the preparation of chiral ionic liquids tweezers”, J. Mol. Liq.

F. Steppeler, M. Górecki, E. Wojaczyńska, “Synthesis of terminal alkynes based on (1S,3R,4R)- and (1S,3S,4R)-2-azabicyclo[2.2.1]heptane”, Arkivoc

B. Naumczuk, M. Górecki, K. Wiktorska, M. Urbanowicz, J. Sitkowski, K. Lubelska, M. Milczarek, E. Bednarek, W. Bocian, L. Kozerski, „New camptothecin derivatives for generalized oncological chemotherapy: synthesis, stereochemistry and biology ”, Bioorg. Med. Chem. Lett.

A. Gołębiowski, T. Kowalkowski, A. Rodzik, P. Pomastowski, A. Król-Górniak, M. Górecki, B. Buszewski, “Isolation and self – association studies of beta – lactoglobulin”, Int. J. Mol. Sci.

K. Olszewska, I. Jastrzębska, A. Łapiński, M. Górecki, R. Santillan, N. Farfán, T. Runka, “Steroidal molecular rotors with 1,4-diethynylphenylene rotators: experimental and theoretical investigations towards seeking efficient properties”, J. Phys. Chem. B

J. Iwanejko, M. Sowiński, E. Wojaczyńska, T. K. Olszewski, M. Górecki, „An approach to new chiral bicyclic imines and amines via Horner–Wadsworth–Emmons reaction”, RSC Adv.

S. Bashiri, J. Abdollahzadeh, R. Di Lecce, D. Alioto, M. Górecki, G. Pescitelli, M. Masi, A. Evidente, „Rabenchromenone and Rabenzophenone, Phytotoxic Tetrasubstituted Chromenone and Hexasubstituted Benzophenone Constituents Produced by the Oak-Decline-Associated Fungus Fimetariella rabenhorstii”, J. Nat. Prod.

F. Del Bello, M. Giannella, G. Giorgioni, A. Piergentili, M. G. Sabbieti, D. Agas, A. Altomare, R. Matucci, G. Pescitelli, M. Górecki, G. Vistoli, W. Quaglia, “Novel potent muscarinic receptor antagonists: investigation on the nature of lipophilic substituents in the 5- and/or 6-positions of the 1,4-dioxane nucleus”, J. Med. Chem.

K. Dhbaibi, C. Shen, M. Jean, N. Vanthuyne, T. Roisnel, M. Górecki, B. Jamoussi, L. Favereau, J. Crassous, “Chiral diketopyrrolopyrrole-helicene polymer with efficient red circularly polarized luminescence”, Front. Chem.

S. Ka, M. Masi, N. Merindol, R. Di Lecce, M. Plourde, M. Seck, M. Górecki, G. Pescitelli, I. Desgagne-Penix, A. Evidente, “Gigantelline, gigantellinine and gigancrinine, cherylline- and crinine-type alkaloids isolated from Crinum jagus with anti-acetylcholinesterase activity”, Phytochemistry

M. Masi, A. Cimmino, F. Salzano, R. Di Lecce, M. Górecki, V. Calabrò, G. Pescitelli, A. Evidente, “Higginsianins D and E, Cytotoxic Diterpenoids Produced by Colletotrichum higginsianum”, J. Nat. Prod.

M. Górecki, J. Frelek, “A critical appraisal of dimolybdenum tetraacetate application in stereochemical studies of vic-diols by circular dichroism”, J. Nat. Prod.

S. Di Silvio, F. Bologna, L. Milli, D. Giuri, N. Zanna, N. Castellucci, M. Monari, M. Calvaresi, M. Górecki, G. Angelici, C. Tomasini, G. Pescitelli, “Elusive π-Helical Foldamers Spotted by Chiroptical Studies”, Org. Biomol. Chem.

M. Masi, P. Reveglia, R. Baaijens-Billones, M. Górecki, G. Pescitelli, S. Savocchia, A. Evidente, “Phytotoxic Metabolites from Three Neofusicoccum Species Causal Agents of Botryosphaeria Dieback in Australia. Luteopyroxin, Neoanthraquinone and Luteoxepinone, a Disubstituted furo-α-pyrone, a Hexasubstituted Anthraquinone and a Trisubstituted Oxepi-2-one from Neofusicoccum luteum”, J. Nat. Prod.

G. Albano, M. Górecki, G. Pescitelli, L. Di Bari, T. Jávorfi, R. Hussain, G. Siligardi, „Electronic Circular Dichroism Imaging (CDi) Maps Local Aggregation Modes in Thin Films of Chiral Oligothiophenes”, New J. Chem.

A. Long, M. Jean, M. Albalat, N. Vanthuyne, M. Giorgi, M. Górecki, J. P. Dutasta, A. Martinez, „Synthesis, resolution and chiroptical properties of hemicryptophane cage controlling the chirality of propeller arrangement of a C3 triamide unit”, Chirality

R. Kutaszewicz, B. Grzeszczyk, M. Górecki, O. Staszewska-Krajewska, B. Furman, M. Chmielewski, „Bypassing the stereoselectivity issue: transformations of Kinugasa adducts from chiral alkynes and non-chiral acyclic nitrones”, Org. Biomol. Chem.

C. Schaack, L. Arrico, E. Sidler, M. Górecki, L. Di Bari, F. Diederich, „Helicene Monomers and Dimers: Chiral Chromophores Featuring Strong Circularly Polarized Luminescence”, Chem. Eur. J.

G. Pescitelli, S. Lüdeke, M. Górecki, L. Di Bari, „Symmetry-Dependent Vibrational Circular Dichroism Enhancement in Co(II) Salicylaldiminato Complexes”, J. Phys. Chem. Lett.

M. Górecki, V. Zullo, A. Iuliano, G. Pescitelli, „On the Absolute Stereochemistry of Tolterodine: A Circular Dichroism Study”, Pharmaceuticals

A. Long, C. Colomban, M. Jean, M. Albalat, N. Vanthuyne, M. Giorgi, L. Di Bari, M. Górecki, J. P. Dutasta, A. Martinez, „Enantiopure C1-Cyclotriveratrylene with a Reversed Spatial Arrangement of the Substituents”, Org. Lett.

D. Jakšić, M. S. Klarić, I. Crnolatac, N. Š. Vujičić, V. Smrečki, M. Górecki, G. Pescitelli, I. Piantanida, “Unique aggregation of sterigmatocystin in water yields strong and specific circular dichroism response allowing highly sensitive and selective monitoring of bio-relevant interactions”, Mar. Drugs

M. Górecki, M. A. M. Capozzi, G. Albano, C. Cardellicchio, L. Di Bari, G. Pescitelli, “Stereochemical analysis of beta-keto sulfoxides by circular dichroism”, Chirality

J. Wei, W. H. Guo, C. Y. Cao, R. W. Kou, Y. Z. Xu, M. Górecki, L. Di Bari, G. Pescitelli, J. M. Gao, “Polyoxygenated cyathane diterpenoids from the mushroom Cyathus africanus, and their neurotrophic and anti-neuroinflammatory activities”, Scientific Reports

S. Superchi, P. Scafato, M. Górecki, G. Pescitelli “Absolute Configuration Determination of Fungal Metabolites by Quantum Mechanical Calculation of Chiroptical Spectra”, Curr. Med. Chem.

G. Angelici, M. Górecki, G. Pescitelli, N. Zanna, M. Monari, C. Tomasini, “Synthesis and Structure Analysis of Ferrocene-Containing Pseudopeptides”, Peptide Science

M. Masnyk, A. Butkiewicz, M. Górecki, R. Luboradzki, P. Paluch, M. Potrzebowski, J. Frelek, “In-Depth Analysis of Chiroptical Properties of Enones Derived from Abietic Acid”, J. Org. Chem.

A. Cimmino, P. Nocera, B. Linaldeddu, M. Masi, M. Górecki, G. Pescitelli, L. Montecchio, L. Maddau, A. Evidente, “Phytotoxic Metabolites Produced by Diaporthella cryptica, the Causal Agent of Hazelnut Branch Canker”, J. Agric. Food Chem.

M. Górecki, L. Arrico, F. Zinna, L. Carpita, L. Di Bari, “Chiroptical Methods in a wide wavelength range for seeking Ln3+ Complexes with Circularly Polarized Luminescence of Practical Interest”, Dalton Trans.

M. Masi, S. Meyer, M. Górecki, G. Pescitelli, S. Clement, A. Cimmino, A. Evidente, “Phytotoxic activity of metabolites isolated from Rutstroemia sp.n., the causal agent of bleach blonde syndrome on cheatgrass (Bromus tectorum)”, Molecules

J. E. Rode, M. Górecki, S. Witkowski, J. Frelek, „Solvation of 2-(hydroxymethyl)-2,5,7,8-tetramethyl-chroman-6-ol revealed by circular dichroism: a case of chromane helicity rule breaking”, Phys. Chem. Chem. Phys.

A. Homberg, E. Brun, F. Zinna, S. Pascal, M. Górecki, L. Monnier, C. Besnard, G. Pescitelli, L. Di Bari, J. Lacour, “Combined reversible switching of ECD and quenching of CPL with chiral fluorescent macrocycles”, Chem. Sci.

G. Pescitelli, S. Lüdeke, A. C. Chamayou, M. Marolt, V. Justus, M. Górecki, L. Arrico, L. Di Bari, M. A. Islam, I. Gruber, M. Enamullah, C. Janiak, “Broad-band spectral analysis for chiral metal coordination compounds: (chiro)optical super-spectrum of chiral cobalt(II) complexes”, Inorg. Chem.

J. Mayans, M. Font-Bardia, L. Di Bari, M. Górecki, A. Escuer, “Chiral [MnIIMnIII3M’] (M’ = Na, CaII, MnII) and [MnIIMnIII6NaI2] clusters built from an enantiomerically pure Schiff base: synthetic, chiroptical and magnetic properties”, Chem. Eur. J.

A. Escuer, J. Mayans, M. Font-Bardia, L. Di Bari, M. Górecki, “Trinuclear Complexes Derived from R/S Schiff Bases – Chiral Single-Molecule-Magnets”, Eur. J. Inorg. Chem.

F. Zinna, C. Resta, M. Górecki, G. Pescitelli, T. Jávorfi, R. Hussain, G. Siligardi, L. Di Bari, “Circular Dichroism Imaging: Mapping the Local Supramolecular Order in Thin Films of Chiral Functional Polymers”, Macromolecules

M. Górecki, F. Zinna, T. Biver, L. Di Bari, “Induced Circularly Polarized Luminescence for Revealing DNA Binding with Fluorescent Dyes”, J. Pharm. Biomed. Anal.

A. Jelińska, A. Zagożdżon, M. Górecki, A. Wiśniewska, J. Frelek, R. Hołyst, “Denaturation of Proteins by Surfactants Studied by Taylor Dispersion Analysis”, PLOS One

A. Escuer, J. Mayans, M. Font-Bardia, M. Górecki, L. Di Bari, “Syntheses, Structures, Chiroptical and Magnetic Properties of Chiral Clusters Built from Schiff Bases: A Novel [MnIIMnIII6NaI2] core”, Dalton Trans.

M. Górecki, A. Dziedzic, R. Luboradzki, A. Ostaszewska, J. Frelek, W. J. Szczepek, “Synthesis and Comprehensive Structural and Physicochemical Characterization of Dutasteride Hydrochloride Hydrate Solvates”, Steroids

M. Górecki, G. Groszek, J. Frelek, „Chirality Sensing of Bioactive Compounds with Amino Alcohol Unit via Circular Dichroism”, Chirality

N. Ur Rehmana, H. Hussain, S. Al-Shidhani, S. K. Avula, G. Abbas, M. Usman Anwar, M. Górecki, G. Pescitelli, A. Al-Harrasi, “Incensfuran: isolation, X-Ray crystal structure and absolute configuration by means of chiroptical studies in solution and solid state”, RSC Adv.

M. Masi, S. Meyer, M. Górecki, A. Mandoli, L. Di Bari, G. Pescitelli, A. Cimmino, M. Cristofaro, S. Clement, A. Evidente, “Pyriculins A and B, two monosubstituted hex-4-ene-2,3-diols and other phytotoxic metabolites produced by Pyricularia grisea isolated from buffelgrass (Cenchrus ciliaris)”, Chirality

M. Masi, A. Cimmino, A. Boari, M. C. Zonno, M. Górecki, G. Pescitelli, A. Tuzi, M. Vurro, A. Evidente, “Colletopyrandione, a new phytotoxic tetrasubstituted indolinilylidenpyra-2,4-dione, and colletochlorins G and H, new tetrasubstituted chroman- and isochroman-3,5-diols isolated from Colletotrichum higginsianum”, Tetrahedron

J. Śniechowska, P. Paluch, G. D. Bujacz, M. Górecki, J. Frelek, D. T. Gryko, M. J. Potrzebowski, “Chiral Crystals from Porphyrinoids Possessing a Very Low Racemization Barrier”, CrystEngComm

M. Masnyk, A. Butkiewicz, M. Górecki, R. Luboradzki, C. Bannwarth, S. Grimme, J. Frelek, “Synthesis and Comprehensive Structural and Chiroptical Characterization of Enones Derived from (-)-alpha-Santonin by Experiment and Theory”, J. Org. Chem.

M. Górecki, P. Roszkowski, D. Błachut, J. K. Maurin, J. Frelek, Z. Czarnocki, “Atropoisomerism in mono- and di-aryl 4-amino-2,6-lutidines”, Eur. J. Org. Chem.

S. K. Avula, H. Hussain, R. Csuk, S. Sommerwerk, P. Liebing, M. Górecki, G. Pescitelli, A. Al-Rawahi, N. Ur Rehman, I. R. Green, A. Al-Harrasi, “5-Epi-Incensole: synthesis, X-Ray crystal structure and absolute configuration by means of ECD and VCD studies in solution and solid state”, Tetrahedron: Asymmetry

M. Górecki, “A Configurational and Conformational Study of (-)-Oseltamivir Using a Multi-Chiroptical Approach”, Org. Biomol. Chem.

J. Frelek, M. Górecki, A. Dziedzic, E. Jabłońska, B. Kamieński, R. K. Wojcieszczyk, R. Luboradzki, W. J. Szczepek, „Comprehensive spectroscopic characterization of finasteride polymorphic forms. Does the form X exist?”, J. Pharmaceut. Sci.

M. Górecki, “Transmission vs. Diffuse Transmission in Circular Dichroism: What to Choose for Probing Solid-State Samples?”, Chirality

M. Jawiczuk, M. Górecki, M. Masnyk, J. Frelek, “Complementarity of electronic and vibrational circular dichroism based on stereochemical studies of vic-diols”, TrAC

M. Górecki, M. Jawiczuk, J. Frelek, “Complementarity of electronic and vibrational circular dichroism spectroscopy in structure determination of vic-amino alcohols”, J. Bioanal. Biomed.

A. Jeziorna, K. Stopczyk, E. Skorupska, K. Luberda-Durnas, M. Oszajca, W. Lasocha, M. Górecki, J. Frelek, M. J. Potrzebowski, „Cyclic dipeptides as a building units of nano- and microdevices: synthesis, properties and structural studies”, Cryst. Growth Des.

Tematyka badań

  • Aplikacje metod chiraloptycznych (ECD, ORD, VCD, ROA, CPL) w analizie stereochemicznej (konfiguracja absolutna, konformacja, oddziaływania międzycząsteczkowe) związków naturalnych i syntetycznych
  • Rozwój spektroskopii dichroizmu kołowego (CD) w fazie stałej do zastosowań w chemii medycznej i materiałowej.