Job Offers

Project/Grant title

Chiral hybrids of quinones and quinols with double anticancer and antimicrobial activity against drug-resistant pathogens as potential agents in hospitalization of cancer treatment.

Job description

Cancer is a crippling and challenging disease. Despite the progress in the development of cancer treatments, there is no suitable cure for most advanced cancers.

Cancer patients are also affected by multidrug resistant (MDR) infections, often associated with considerable morbidity and mortality. On the basis of the literature reports, naturally occurring quinones and quinols have been identified as groups of compounds with both of these activities.

Our preliminary results show that the decarboxylative coupling reaction is a convenient tool for the synthesis of variously substituted quinones, which can be further transformed to quinols. However, a stereoselective variant of this is available.

The reaction remains unknown. The main topic of the project is to develop a selective decarboxylative cross-coupling reaction using various aromatic and aliphatic chiral nonracemic acids. After optimisation, a compound library will be prepared and used for biological assays for antimicrobial and anticancer activity. The results obtained will be correlated with the dual inhibition properties towards enzymes recognised in cancer therapy, thioredoxin reductase 1 (TrxR1) and tyrosinase.

Anticancer cell assay and part of antimicrobial assays will be conducted in cooperation with our partners from the European Network Action COST CA21145 for the diagnosis and treatment of antibiotic-resistant bacterial infections (EURESTOP). The Molecular Knocking of selected compounds with enzymes will be carried out with our partner from the COST CA21162 action, Establishing a Pan-European Network on Computational Redesign of Enzymes (COZYME).

Description of tasks: Analysis of data collected in our team and analysis of literature data. Synthesis of chiral substrates. Performing catalytic decarboxylative coupling reactions. Preparation of reports and manuscripts.

Researcher profile

R1

Number of positions available

1

Offer

Terms of employment: scholarship for 48 months – stipend (including employer’s costs) 5,000 PLN (ca. 4950 PLN net) per month paid from grant for 39 months + stipend after the end of the grant

Benefits: private medical care package, access to the dormitory for PhD students

Career development opportunities: work in dynamic team, access to research infrastructure, professional development in the field of asymmetric synthesis, the possibility of cooperation with foreign research centers, the possibility of further professional development at the IOC PAS

Additional information

Project manager: prof. Ryszard Ostaszewski

Phone: +48 22 3432054

e-mail: ryszard.ostaszewski@icho.edu.pl

Requirements

Admission to doctoral studies at Warsaw PhD School in Natural and BioMedical Sciences (Warsaw-4-PhD)

Required competencies

  • excellent knowledge of organic chemistry,
  • data analysis and interpretation of experimental data (NMR, MS, UV/Vis), especially in trouble shooting during the research;
  • basic knowledge of rules and protocols valid in organic chemistry labs;
  • effective written and oral communication in English

Desirable competences

  • demonstrated experience in research work will be an asset;
  • creativity, independence, and responsibility
  • strong ability to work independently,

List of required documents

  • scientific curriculum vitae, including a list of scientific achievements (scholarships, publications, conference presentations, etc.);
  • motivation letter;
  • one recommendation letter;
  • a transcript of the grades/credits received; during the last stage of studies and grade point average.
  • consent to the processing of the Candidate’s personal data for the purposes of the competition

Along with the required documents, please submit (or send a scan) a signed consent to the processing of personal data available at: https://www.icho.edu.pl/en/cooperations/career/

Candidate evaluation criteria

  • Candidate’s competence relevant to the project,
  • knowledge of organic chemistry,
  • scientific achievements measured by the quality and quantity of scientific publications awards or distinctions.
  • Opinion about the Candidate contained in the letter of recommendation,
  • language knowledge enabling conducting scientific research.

Deadline for submitting applications

2024-07-15 23:59

Competition settlement date

2024-07-22

Envisaged job starting date: 1.10.2024

Submitting applications

Secretariat

Institute of Organic Chemistry of the Polish Academy of Sciences

Kasprzaka 44/52 Street

01-224 Warsaw

Phone: +48 22 631 8788

e-mail: rekrutacja@icho.edu.pl

ATTENTION! In the title of the e-mail, please enter “Recruitment – Ryszard Ostaszewski”

Project/Grant title

Ambipolar, bowl-shaped polyaromatic compounds with manifold, precisely arranged, nitrogen dopants. Unprecedented class of efficient OLED emitters (BOwLEDs).

Job description

The scope of duties includes analysis of the literature on non-planar organic compounds, TADF active materials, the chemistry of nanografenes, aromatic compounds and transformations enabling the implementation of the proposed synthetic pathways, optimization and carrying out of organic syntheses on a laboratory and preparative scale, purification and isolation of compounds intermediates by means of precipitation, maceration, crystallization, column chromatography. Identification of obtained compounds by using spectroscopic tools and critical analysis of obtained results, their presentation (team seminars) and written two-weeks reports. PhD student will visit a laboratory of Prof. Przemysław Data to get practical knowledge regarding OLEDs fabrication and their analysis. Furthermore, prospective PhD students will be obliged to take a part and pass dedicated lectures (Warsaw4PhD doctoral school), soft-skills, and English courses She/He will be responsible for combining and preparing supplementary information for manuscripts

Researcher profile

R1

Number of positions available

1

Offer

Terms of employment scholarship for 48 months – stipend (including employer’s costs) 5,000 PLN (~4950 PLN gross) per month paid from grant for 28 months with possibility of extension + stipend after the end of the grant

Benefits: private medical care package, co-financing of sports cards, possibility of accommodation at the Doctoral dorm.

Career development opportunities: work in young and dynamic research group;

  • access to modern research infrastructure of IOC PAS;
  • access to modern laboratory equipment
  • professional development in the field organic chemistry, transition metal catalyzed reaction
  • opportunity to participate in national and international scientific conferences and workshops;
  • opportunity for further professional development in IOC PAS.

Additional information

Project manager: Marcin Lindner, PhD

Phone: 22 343 2106

e-mail: marcin.lindner@icho.edu.pl

Requirements

Admission to doctoral studies at Warsaw PhD School in Natural and BioMedical Sciences (Warsaw-4-PhD)

 

Required competencies

  • MSc degree in chemical science (or related areas) or the expected date of obtaining the master degree before starting work;
  • good knowledge in organic synthesis,
  • communicate well in English in writing and in oral and visual presentation, and be able to write reports and manuscripts for publication in scientific journals;
  • be highly motivated and have a strong commitment to research, curiosity, creativity and passion;

Desirable competences

  • experience in synthetic organic chemistry;
  • previous experience in organometalic chemistry, radical chemistry, safe handling of air/water sensitive materials, Schlenk techniques;
  • creativity, responsibility, independence, as well ability to work in team;

List of required documents

  • Candidate’s Curriculum Vitae
  • description of scientific achievements, including a list of publications, ongoing projects, etc.
  • diplomas and certificates confirming qualifications, completed courses, completed training, etc.
  • cover letter
  • letters of recommendation and references from previous employers/supervisors
  • consent to the processing of the Candidate’s personal data for the purposes of the competition

Along with the required documents, please submit (or send a scan) a signed consent to the processing of personal data available at: https://www.icho.edu.pl/en/cooperations/career/

Candidate evaluation criteria

  • scientific achievements measured by the quality and quantity of scientific publications or granted/pending patents
  • Candidate’s professional experience
  • creativity and independence in conducting research
  • career mobility (research internships, work in industry, change of scientific profile)
  • ability to work in a team/ability to transfer knowledge/managerial predispositions
  • awards or distinctions
  • opinions about the Candidate contained in the letters of recommendation
  • language knowledge enabling conducting scientific research

The Candidate will be selected on the basis of the submitted application

Deadline for submitting applications

2024-07-12

Competition settlement date

2024-07-19

Envisaged job starting date: 01.10.2024

Submitting applications

Secretariat

Institute of Organic Chemistry of the Polish Academy of Sciences

Kasprzaka 44/52 Street

01-224 Warsaw

Phone: +48 22 631 8788

e-mail: rekrutacja@icho.edu.pl

ATTENTION! In the title of the e-mail, please enter “Recruitment – Marcin Lindner

Project/Grant title

Approaching 20% emission efficiency in the NIR-II region with radical chromophores 

Job description

The overarching goal of this project is to uncover a strategy to create radicals which at the same time: (a) strongly emit light in the NIR-II region; (b) are stable under ambient conditions; (c) strongly absorb light; (d) display large circularly polarized luminescence. The primary objective of ARCHIMEDES is to deliver breakthrough organic materials possessing large fluorescence quantum yields and stable radical structures in the integrated fields of molecular design, chromophore synthesis and fluorescence imaging of living cells. The realization of ARCHIMEDES will be based on both expanding the chemical space of stable, emissive C-centered radicals and on heretofore nonexisting emissive nitroxide radicals. The synergistic effects of increased brightness of NIR-II dyes and the higher sensitivity and resolution offered by CPL fluorophores will provide quality fluorescence imaging on a previously unthinkable level.

Researcher profile

R1

Number of positions available

4

Offer

Terms of employment: scholarship for 48 months – stipend (including employer’s costs) 8,100 PLN (ca. 6,200 PLN net)

Benefits: private medical care package, co-financing of sports cards, possibility of accommodation at the Doctoral Hotel

Career development opportunities:. work in a young, dynamically developing team, access to research infrastructure, professional development in the field of supramolecular chemistry, work with outstanding specialists, the possibility of cooperation with foreign research centers, the possibility of further professional development at the IOC PAS.

Additional information

Project manager: prof. Daniel Gryko

Phone (+ 48) 22 343 23 21

e-mail: daniel.gryko@icho.edu.pl

Requirements

A prerequisite for qualifying for the project is the PhD student status at the Warsaw PhD School in Natural and BioMedical Sciences (the deadline for submitting documents to the doctoral school is June 2, 2024, the interviews will be held on 06–03.07.2024; details are available on the website https://www.icho.edu.pl/en/phd-students/phd-school/ and https://warsaw4phd.eu/en/admissions/

required competencies: MSc degree in chemistry. Basic experience in organic synthesis and interpretation of spectral data, good communication skills in English.

desirable competences: experience in heterocyclic chemistry

List of required documents

  • Candidate’s Curriculum Vitae
  • description of scientific achievements, including a university record, list of publications, ongoing projects, etc.
  • diplomas and certificates confirming qualifications, completed courses, completed training, etc.
  • cover letter
  • letters of recommendation and references from previous employers/supervisors
  • consent to the processing of the Candidate’s personal data for the purposes of the competition

Along with the required documents, please submit (or send a scan) a signed consent to the processing of personal data available at: https://www.icho.edu.pl/en/cooperations/career/

Candidate evaluation criteria

  • scientific achievements measured by the university scores and scientific publications
  • General organic chemistry knowledge based on an interview
  • Candidate’s professional experience
  • career mobility (research internships, work in industry, change of scientific profile)
  • awards or distinctions
  • opinions about the Candidate contained in the letters of recommendation
  • language knowledge enabling conducting scientific research

Deadline for submitting applications

2024-07-03 23:59

Competition settlement date

2024-07-15 23:59

Envisaged job starting date: 01.10.2024

Submitting applications

Secretariat

Institute of Organic Chemistry of the Polish Academy of Sciences

Kasprzaka 44/52 Street

01-224 Warsaw

Phone: +48 22 631 8788

e-mail: rekrutacja@icho.edu.pl

ATTENTION! In the title of the e-mail, please enter “Recruitment – Daniel Gryko”

Candidates who are not PhD Students of the Doctoral School must take part in the recruitment process to the Warsaw-4-PhD Doctoral School!

Project/Grant title

Peptide-based luminescent coordination capsules and cages

Job description

Peptide-based luminescent coordination capsules and cages) Synthesis of building blocks and complexation experiments, interpretation of spectral data, preparation of data for the publication process.

Researcher profile

R1

Number of positions available

1

Offer

Terms of employment: scholarship for 48 months – stipend (including employer’s costs) 5,000 PLN (~4950 PLN gross) per month paid from grant for 39 months with possibility of extension + stipend after the end of the grant

Type of contract:  temporary (39 months with possibility of extension + stipend after the end of the grant)

Benefits: private medical care package, co-financing of sports cards, possibility of accommodation at the Doctoral Hotel

Career development opportunities:. work in a young, dynamically developing team, access to research infrastructure, professional development in the field of supramolecular chemistry, work with outstanding specialists, the possibility of cooperation with foreign research centers, the possibility of further professional development at the IOC PAS.

Additional information

Project manager: prof. Agnieszka Szumna

Phone (+ 48) 22 343 2203

e-mail: agnieszka.szumna@icho.edu.pl

Candidates who are not PhD Students of the Doctoral School must take part in the recruitment process to the Warsaw-4-PhD Doctoral School!

Requirements

A prerequisite for qualifying for the project is the PhD student status at the Warsaw PhD School in Natural and BioMedical Sciences (the deadline for submitting documents to the doctoral school is June 2, 2024, the interviews will be held on 06–03.07.2024; details are available on the website https://www.icho.edu.pl/en/phd-students/phd-school/ and https://warsaw4phd.eu/en/admissions/

  • required competencies: MSc degree in chemistry, pharmacy, biotechnology, or physics. Basic experience in organic synthesis and interpretation of spectral data, good communication skills in English.
  • desirable competences: experience in supramolecular chemistry

List of required documents

  • Candidate’s Curriculum Vitae
  • description of scientific achievements, including a university record, list of publications, ongoing projects, etc.
  • diplomas and certificates confirming qualifications, completed courses, completed training, etc.
  • cover letter
  • letters of recommendation and references from previous employers/supervisors
  • consent to the processing of the Candidate’s personal data for the purposes of the competition

Along with the required documents, please submit (or send a scan) a signed consent to the processing of personal data available at: https://www.icho.edu.pl/en/cooperations/career/

Candidate evaluation criteria

  • scientific achievements measured by the university scores and scientific publications
  • General organic chemistry knowledge based on an interview
  • Candidate’s professional experience
  • career mobility (research internships, work in industry, change of scientific profile)
  • awards or distinctions
  • opinions about the Candidate contained in the letters of recommendation
  • language knowledge enabling conducting scientific research

Deadline for submitting applications

2024-07-03 23:59

Competition settlement date

2024-07-15 23:59

Envisaged job starting date: 01.10.2024

Submitting applications

Secretariat

Institute of Organic Chemistry of the Polish Academy of Sciences

Kasprzaka 44/52 Street

01-224 Warsaw

Phone: +48 22 631 8788

e-mail: rekrutacja@icho.edu.pl

ATTENTION! In the title of the e-mail, please enter “Recruitment – Agnieszka Szumna”

Project/Grant title

Palladium-catalyzed cascades for the rapid and enantioselective construction of polycyclic scaffolds of alkaloids and pseudo-natural products

Job description

The aim of the project is the development of palladium-catalyzed cascade reactions forming polycyclic nitrogen-containing structures, corresponding to the skeletons of natural alkaloids and their analogues. An important goal is to design and optimize these catalytic reactions also in enantioselective manner by performing them in the presence of chiral ligands. The work will involve multi-step syntheses of the precursors for the Pd-catalyzed cascade reactions, optimization of the cascade reactions, spectroscopic and HPLC analysis of the products, preparation of the results for publication.

Researcher profile

R1

Number of positions available

1

Offer

  • Terms of employment: scholarship for 48 months – stipend (including employer’s costs) 5,000 PLN per month (ca. 4950 PLN net) paid from grant for 32 months + stipend after the end of the grant

 

Type of contract: temporary

Job status: full time

 

Hours per week: 40

 

  • Benefits: medical care package, co-financing of sports cards, possibility of accommodation at the Doctoral Hotel
  • Career development opportunities: professional development in the field of organic synthesis and analysis of organic compounds, access to research infrastructure, the possibility of further professional development at the IOC PAS)

Additional information

Project manager: Assoc. Professor Rafał Loska

Phone: +48 22 343 2108, +48 602 855 591

e-mail: rafal.loska@icho.edu.pl

www.icho.edu.pl/zespol/rafal-loska

Candidates who are not PhD Students of the Doctoral School must take part in the recruitment process to the Warsaw-4-PhD Doctoral School!

Requirements

 

  • required competencies

– A MsC degree in chemistry

– good knowledge of organic chemistry

– basic laboratory experience

  • desirable competences

– dedication to the project, interpersonal skills

– good English language skills, sufficient for research work in chemistry

List of required documents

  • Candidate’s Curriculum Vitae
  • description of scientific achievements, including a list of publications, ongoing projects, etc.
  • diplomas and certificates confirming qualifications, completed courses, completed training, etc.
  • cover letter
  • letters of recommendation and references from previous employers/supervisors
  • consent to the processing of the Candidate’s personal data for the purposes of the competition

Along with the required documents, please submit (or send a scan) a signed consent to the processing of personal data available at: https://www.icho.edu.pl/en/cooperations/career/

Candidate evaluation criteria

  • scientific achievements measured by the quality and quantity of scientific publications or granted/pending patents
  • Candidate’s professional experience
  • creativity and independence in conducting research
  • career mobility (research internships, work in industry, change of scientific profile)
  • ability to work in a team
  • awards or distinctions
  • opinions about the Candidate contained in the letters of recommendation
  • language knowledge enabling conducting scientific research
  • grades obtained during undergraduate studies

Deadline for submitting applications

5th July 2024 12:00

Competition settlement date

12th July 2024

Envisaged job starting date: 1st October 2024

Submitting applications

Secretariat

Institute of Organic Chemistry of the Polish Academy of Sciences

Kasprzaka 44/52 Street

01-224 Warsaw

Phone: +48 22 631 8788

e-mail: rekrutacja@icho.edu.pl

ATTENTION! In the title of the e-mail, please enter “Recruitment – Rafał Loska”

Project/Grant title

RED LIGHT – A TOOL FOR ORGANIC AND BIOORTHOGONAL CHEMISTRY

Job description

In particular, the main tasks will involve:

– elaborating reactions in physiological conditions

– testing developed reactions on model, short peptides and oligonucleotides

– analytical characterization of synthesized compounds.

Researcher profile

R1

Number of positions available

1

Offer

Terms of employment: scholarship for 48 months – stipend (including employer’s costs) 5,000 PLN (around net 4950 PLN) per month paid from grant for 7 months + stipend after the end of the grant

  • Benefits: private medical care package, access to the dormitory for PhD students
  • Career development opportunities:
  • work in dynamic team,
  • access to research infrastructure,
  • professional development in the field of photocatalysis,
  • the possibility of further professional development at the IOC PAS

The successful candidate will be part of a highly experienced, multi-disciplinary team. She/He will have the possibility to broaden her/his knowledge and gain hands-on experience at the border between theory and experiment.

Additional information

Project manager: Dorota Gryko

Phone: +48 22 343 20 51

e-mail: dorota.gryko@icho.edu.pl

Candidates who are not PhD Students of the Doctoral School must take part in the recruitment process to the Warsaw-4-PhD Doctoral School!

Requirements

 

  • required competences
    • experience in organic chemistry or related;
    • other skills include analysis and interpretation of experimental data (NMR, MS, UV/Vis);
    • demonstrated experience in research work will be an asset;
    • good written and oral communication skills in English;
    • Personal skills: strong motivation for scientific work, ambition, creativity, goal-orientation, responsibility, ability to work independently as well as in a group; excellent communications, organization and time management skills, willingness to learn, analytical thinking and critical problem solving skills;
  • desirable competences
    • excellent knowledge of organic chemistry and organometallic chemistry,
    • data analysis and interpretation, especially in trouble shooting during the research;
    • basic knowledge of rules and protocols valid in organic chemistry labs;

List of required documents

  • scientific curriculum vitae, including a list of scientific achievements (scholarships, publications, conference presentations, etc.);
  • motivation letter;
  • one recommendation letter;
  • a transcript of the grades/credits received; during the last stage of studies and grade point average.

Along with the required documents, please submit (or send a scan) a signed consent to the processing of personal data available at: https://www.icho.edu.pl/en/cooperations/career/

Candidate evaluation criteria

  • competences of candidates for specific tasks in a research project
  • previous scientific achievements of candidates
  • awards and distinctions of the candidate resulting from the conducted research
  • language knowledge enabling conducting scientific research

Deadline for submitting applications

2024-06-02 14:00

Competition settlement date

2024-07-15

Envisaged job starting date: 01.10.2024

Submitting applications

Secretariat

Institute of Organic Chemistry of the Polish Academy of Sciences

Kasprzaka 44/52 Street

01-224 Warsaw

Phone: +48 22 631 8788

e-mail: rekrutacja@icho.edu.pl

ATTENTION! In the title of the e-mail, please enter “Recruitment – Dorota Gryko – PHD2”

Project/Grant title

RED LIGHT – A TOOL FOR ORGANIC AND BIOORTHOGONAL CHEMISTRY

Job description

In particular, the main tasks will involve:

– developing water-soluble photocatalysts,

– developing red-light induced reactions in water

– analytical characterization of synthesized compounds

Researcher profile

R1

Number of positions available

1

Offer

Terms of employment: scholarship for 48 months – stipend (including employer’s costs) 5,000 PLN (around net 4950 PLN) per month paid from grant for 18 months + stipend after the end of the grant

  • Benefits: private medical care package, access to the dormitory for PhD students
  • Career development opportunities:
  • work in dynamic team,
  • access to research infrastructure,
  • professional development in the field of photocatalysis,
  • the possibility of further professional development at the IOC PAS

The successful candidate will be part of a highly experienced, multi-disciplinary team. She/He will have the possibility to broaden her/his knowledge and gain hands-on experience at the border between theory and experiment.

Additional information

Project manager: Dorota Gryko

Phone: +48 22 343 20 51

e-mail: dorota.gryko@icho.edu.pl

Candidates who are not PhD Students of the Doctoral School must take part in the recruitment process to the Warsaw-4-PhD Doctoral School!

Requirements

 

  • required competences
    • experience in organic chemistry or related;
    • other skills include analysis and interpretation of experimental data (NMR, MS, UV/Vis);
    • demonstrated experience in research work will be an asset;
    • good written and oral communication skills in English;
    • Personal skills: strong motivation for scientific work, ambition, creativity, goal-orientation, responsibility, ability to work independently as well as in a group; excellent communications, organization and time management skills, willingness to learn, analytical thinking and critical problem solving skills;
  • desirable competences
    • excellent knowledge of organic chemistry and organometallic chemistry,
    • data analysis and interpretation, especially in trouble shooting during the research;
    • basic knowledge of rules and protocols valid in organic chemistry labs;

List of required documents

  • scientific curriculum vitae, including a list of scientific achievements (scholarships, publications, conference presentations, etc.);
  • motivation letter;
  • one recommendation letter;
  • a transcript of the grades/credits received; during the last stage of studies and grade point average.

Along with the required documents, please submit (or send a scan) a signed consent to the processing of personal data available at: https://www.icho.edu.pl/en/cooperations/career/

Candidate evaluation criteria

  • competences of candidates for specific tasks in a research project
  • previous scientific achievements of candidates
  • awards and distinctions of the candidate resulting from the conducted research
  • language knowledge enabling conducting scientific research

Deadline for submitting applications

2024-06-02 14:00

Competition settlement date

2024-07-15

Envisaged job starting date: 01.10.2024

Submitting applications

Secretariat

Institute of Organic Chemistry of the Polish Academy of Sciences

Kasprzaka 44/52 Street

01-224 Warsaw

Phone: +48 22 631 8788

e-mail: rekrutacja@icho.edu.pl

ATTENTION! In the title of the e-mail, please enter “Recruitment – Dorota Gryko – PHD1”

Recruitment results are sent to all candidates by e-mail to the address indicated in the application immediately after the selection process is completed. The ranking list is available from the contact person indicated in the announcement and from the Human Resources Department of the Institute of Organic Chemistry of the PAS.

 

 

Additional documents required to be submitted to the HR department: