“Targeting MMP-9 in Cancer Treatment: Computational Design and Experimental Validation of Potent, Safe Antitumor Agents”
The aim of this project is to accelerate the discovery of safe and effective matrix metalloproteinase 9 (MMP 9) inhibitors through advanced AI assisted drug design. We anticipate that the use of state of the art medicinal chemistry software, incorporating both retrosynthetic and forward synthetic algorithms, will enable the generation of novel yet synthetically accessible chemical entities. The workflow will begin with computational modeling to generate hundreds to thousands of candidate molecules, followed by rapid prediction of their binding affinity to the MMP 9 enzyme, as well as evaluation of key pharmacokinetic properties. The most promising compounds will be further assessed using molecular docking to evaluate binding modes and selectivity, and molecular dynamics simulations to estimate the stability of ligand protein interactions. This approach will allow us to prioritize compounds with the highest likelihood of success, namely those combining strong inhibitory activity against MMP 9, selectivity over other MMP isoforms, and favorable drug like and safety profiles. The top candidates will be synthesized in the laboratory and evaluated in cell based assays to confirm their anticancer potential.
In particular, the main tasks will involve:
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1
Terms of employment: scholarship for 43 months, with a possible extension to 48 months; funded by an NCN grant – a scholarship of 5,000 PLN per month, including employer costs, until the month in which the doctoral student’s mid-term evaluation is conducted; a scholarship of 6,500 PLN per month, including employer costs, starting from the month following the doctoral student’s mid-term evaluation. The salary level is consistent with the compensation guidelines for comparable student positions in projects funded by the National Science Centre.
Benefits:
Career development opportunities: work in a dynamically developing team, access to research infrastructure, professional development in the field of organic synthesis, computational drug design, work with outstanding specialists in the field of organic and computational chemistry, the possibility of cooperation with foreign research centers (e.g. UNIST South Korea), the possibility of further professional development at the IOC PAS, participation in national and international conferences
Project manager: Dr Anna Żądło-Dobrowolska
Head of Research Group: Prof. Bartosz Grzybowski
e-mail: anna.zadlo@icho.edu.pl
We are an open and inclusive employer – we encourage applications from all individuals, regardless of gender, origin, nationality, or minority background.

A prerequisite for qualifying for the project is the status of being a PhD student at a Doctoral School. Individuals who do not currently hold this status are required to apply for admission to the Warsaw-4-PhD School. Full details regarding the recruitment process are available on the school’s website. Applications must be submitted via the official doctoral school recruitment system.
required competences
desirable competences
Along with the required documents, please submit (or send a scan) a signed consent to the processing of personal data available at: https://www.icho.edu.pl/en/cooperations/career/
Job interviews with candidates are scheduled to take place from June 24, 2026, to July 3, 2026.
31.05.2026
07.07.2026r.
Envisaged job starting date: 01.10.2026
Secretariat
Institute of Organic Chemistry of the Polish Academy of Sciences
Kasprzaka 44/52 Street
01-224 Warsaw
Phone: +48 22 631 8788
e-mail: rekrutacja@icho.edu.pl
ATTENTION! In the title of the e-mail, please enter “Recruitment – Anna Żądło-Dobrowolska”
Candidates who are not PhD Students of the Doctoral School must take part in the recruitment process to the Warsaw-4-PhD Doctoral School! Please apply via online registration.
If you have an active status of a PhD Student in a Doctoral School in Poland, please apply by e-mail: rekrutacja@icho.edu.pl
“Unlocking Access to New Bioisosteric Motifs: Radical Reactions and Reagents for the Incorporation of NCF3 and NCF2H Functional Groups”
The main tasks will involve:
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1
Terms of employment: full-time employment for 12 months with the possibility of extension up to 36 months, with salary funded by the NCN grant, 11666,66 PLN (gross gross) ~9700 PLN gross; The salary level is in line with the compensation guidelines for comparable postdoctoral positions in projects funded by the National Science Centre.
Benefits:
Career development opportunities:
Project manager: dr Michał Ociepa
Phone: +48 509-610-806
e-mail: michal.ociepa@icho.edu.pl (preferred)
We are an open and inclusive employer – we encourage applications from all individuals, regardless of gender, origin, nationality, or minority background.

Maximum 7 years after completion of PhD – requirement of financing institution
required competences
desirable competences
Along with the required documents, please submit (or send a scan) a signed consent to the processing of personal data available at: https://www.icho.edu.pl/en/cooperations/career/
12.06.2026 23:59 [GMT+1]
30.06.2026
Envisaged job starting date: 01.10.2026
Secretariat
Institute of Organic Chemistry of the Polish Academy of Sciences
Kasprzaka 44/52 Street
01-224 Warsaw
Phone: +48 22 631 8788
Please apply by e-mail: rekrutacja@icho.edu.pl
ATTENTION! In the title of the e-mail, please enter “Recruitment – POST-DOC – Michal Ociepa”
“Opracowanie nowej usługi odkrywania związków małocząsteczkowych o potencjale terapeutycznym wykorzystującej modele sztucznej inteligencji”
FENG.01.01-IP.01-A12Q/25-00
The objective of the planned research is the synthesis of model compounds. The list of required structures is provided by Molecure SA, a consortium member, and may be subject to modification.
Responsibilities: Synthesis of model compounds belonging mainly to the class of aromatic and heterocyclic compounds (approximately 100–130 substances annually), in quantities of approximately 100–150 mg each. This includes the synthesis of new compounds (not described in chemical databases) using short synthetic pathways (typically 2–3 steps). It requires the ability to adapt known methodologies used for analogous compounds to the synthesis of target molecules.
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1
Terms of employment: Full-time position for 12 months, with the possibility of extension depending on the grant budget; monthly salary of 11,000 PLN gross corresponding to the level of remuneration offered for comparable positions at the Institute of Organic Chemistry PAS in projects funded from external sources.
Benefits:
Career development opportunities:
Team leader: prof. Jacek Młynarski
e-mail: jacek.mlynarski@icho.edu.pl

We are an open and inclusive employer – we encourage applications from all individuals, regardless of gender, origin, nationality, or minority background.

PhD degree in chemistry (specialization in organic chemistry)
required competences
desirable competences
Along with the required documents, please send a scan of a signed consent to the processing of personal data available below.
The Candidate will be selected on the basis of the submitted application.
20.05.2026, 23:59
22.05.2026 r.
Envisaged job starting date: 01.06.2026 r.
Secretariat
Institute of Organic Chemistry of the Polish Academy of Sciences
Kasprzaka 44/52 Street
01-224 Warsaw
Phone: +48 22 631 8788
Please apply by e-mail: rekrutacja@icho.edu.pl
ATTENTION! In the title of the e-mail, please enter “Recruitment – Jacek Mlynarski”
“Center for Quantum Digital Organic Memristors”
FENG.02.01-IP.05.-M005/25
The „Center for Quantum Digital Organic Memristors” project is carried out within the International Research Agendas (MAB FENG) programme of the Foundation for Polish Science co-financed by the European Union under the European Funds for Smart Economy 2021-2027 (FENG).
The Quantum Digital Organic Memristor Center (CKCOM) project focuses on the development of a new generation of molecular memory and logic elements based on quantum proton tunneling. The objective is to advance energy-efficient memcomputing technologies that integrate information processing and storage within single molecular systems, with potential applications in nanoelectronics and artificial intelligence systems.
The successful candidate will be employed as a researcher at CKCOM and will prepare a doctoral dissertation in the extramural mode, while attending lectures at the Warsaw4PhD Doctoral School. The research will be conducted in Dr. Marek Grzybowski’s group. The work will involve the synthesis of organic compounds—specifically aromatic amino acids—which, according to theoretical predictions, should exhibit a memristive switching effect between two electrical conductivity states: low and high. Following experimental verification, the synthesized derivatives will be used to construct next-generation memristive elements.
Accepting this position entails a commitment to prepare a doctoral dissertation in a field consistent with the project’s subject matter, under the supervision of the Research Team Leader.
The main tasks will involve:
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1
Terms of employment: Full-time employment for 36-month, including a 3-month probationary period; a monthly salary of approximately 8 300 PLN gross, corresponding to the level of remuneration offered for comparable positions at the Institute of Organic Chemistry PAS in projects funded from external sources.
Benefits:
Career development opportunities: The selected candidate will have the opportunity to pursue extramural studies to prepare their doctoral dissertation. We offer work in a dynamically developing international team, access to advanced research infrastructure, opportunities for collaboration with foreign research centers, opportunities for further professional development at the Institute of Organic Chemistry of the Polish Academy of Sciences, and participation in training courses and scientific conferences abroad.
Group Lider: Dr. Marek Grzybowski
Phone: +48 22 3432035
e-mail: marek.grzybowski@icho.edu.pl

We are an open and inclusive employer – we encourage applications from all individuals, regardless of gender, origin, nationality, or minority background.

required competences
desirable competences
Along with the required documents, please submit (or send a scan) a signed consent to the processing of personal data available at: https://www.icho.edu.pl/en/cooperations/career/
31.05.2026 23:00 CET
12.06.2026
Envisaged job starting date: 15.06.2026
Secretariat
Institute of Organic Chemistry of the Polish Academy of Sciences
Kasprzaka 44/52 Street
01-224 Warsaw
Phone: +48 22 631 8788
Applications must be sent to e-mail address: rekrutacja@icho.edu.pl
ATTENTION! In the title of the e-mail, please enter reference number “CKCOM/2026/D/1”
“Unlocking Access to New Bioisosteric Motifs: Radical Reactions and Reagents for the Incorporation of NCF3 and NCF2H Functional Groups”
The main tasks will involve:
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1
Terms of employment: scholarship for 48 months (01.10.2026 – 30.09.2030) – stipend 5,000 PLN gross gross per month paid for the first 24 months; 6,500 PLN gross gross per month for the last 24 month (after evaluation period), funded by an NCN grant. The salary level is consistent with the compensation guidelines for comparable student positions in projects funded by the National Science Centre.
Benefits:
Career development opportunities:
Project manager: Michał Ociepa
e-mail: michal.ociepa@icho.edu.pl
We are an open and inclusive employer – we encourage applications from all individuals, regardless of gender, origin, nationality, or minority background.

A prerequisite for qualifying for the project is the status of being a PhD student at a Doctoral School. Individuals who do not currently hold this status are required to apply for admission to the Warsaw-4-PhD School. Full details regarding the recruitment process are available on the school’s website. Applications must be submitted via the official doctoral school recruitment system.
Required competencies
Desirable competences
Along with the required documents, please submit (or send a scan) a signed consent to the processing of personal data available at: https://www.icho.edu.pl/en/cooperations/career/
Job interviews with candidates are scheduled to take place from June 24, 2026, to July 3, 2026.
31.05.2026
10.07.2026
Envisaged job starting date: 01.10.2026
Secretariat
Institute of Organic Chemistry of the Polish Academy of Sciences
Kasprzaka 44/52 Street
01-224 Warsaw
Phone: +48 22 631 8788
e-mail: rekrutacja@icho.edu.pl
ATTENTION! In the title of the e-mail, please enter “Recruitment – Michal Ociepa”
Candidates who are not PhD Students of the Doctoral School must take part in the recruitment process to the Warsaw-4-PhD Doctoral School! Please apply via online registration.
If you have an active status of a PhD Student in a Doctoral School in Poland, please apply by e-mail: rekrutacja@icho.edu.pl
“Interfacial photoelectrochemistry for modern organic synthesis”
In particular, the main tasks will involve:
R1
1
Terms of employment: scholarship for 48 months: for 35 months scholarship with the possibility of extension to 48 months, funded by an NCN grant – a scholarship of 5,000 PLN per month, including employer costs, until the month in which the doctoral student’s mid-term evaluation is conducted; a scholarship of 6,500 PLN per month, including employer costs, starting from the month following the doctoral student’s mid-term evaluation. The salary level is consistent with the compensation guidelines for comparable student positions in projects funded by the National Science Centre.
Benefits:
Career development opportunities:
Project manager: Katarzyna Rybicka-Jasińska
e-mail: katarzyna.rybicka-jasinska@icho.edu.pl
We are an open and inclusive employer – we encourage applications from all individuals, regardless of gender, origin, nationality, or minority background.

A prerequisite for qualifying for the project is the status of being a PhD student at a Doctoral School. Individuals who do not currently hold this status are required to apply for admission to the Warsaw-4-PhD School. Full details regarding the recruitment process are available on the school’s website. Applications must be submitted via the official doctoral school recruitment system.
required competences
desirable competences
Along with the required documents, please submit (or send a scan) a signed consent to the processing of personal data – template available below.
Job interviews with candidates are scheduled to take place from June 24, 2026, to July 3, 2026.
31.05.2026
07.07.2026r.
Envisaged job starting date: 01.10.2026
Secretariat
Institute of Organic Chemistry of the Polish Academy of Sciences
Kasprzaka 44/52 Street
01-224 Warsaw
Phone: +48 22 631 8788
e-mail: rekrutacja@icho.edu.pl
ATTENTION! In the title of the e-mail, please enter “Recruitment – Katarzyna Rybicka-Jasińska”
Candidates who are not PhD Students of the Doctoral School must take part in the recruitment process to the Warsaw-4-PhD Doctoral School! Please apply via online registration.
If you have an active status of a PhD Student in a Doctoral School in Poland, please apply by e-mail: rekrutacja@icho.edu.pl
“Center for Quantum Digital Organic Memristors”
FENG.02.01-IP.05.-M005/25
The „Center for Quantum Digital Organic Memristors” project is carried out within the International Research Agendas (MAB FENG) programme of the Foundation for Polish Science co-financed by the European Union under the European Funds for Smart Economy 2021-2027 (FENG).
The Center for Quantum Digital Organic Memristors (CKCOM) project focuses on the development of a new generation of molecular memory and logic elements based on proton quantum tunneling. The aim is to advance energy-efficient memcomputing technologies that integrate information processing and storage within single molecular systems, with potential applications in nanoelectronics and AI systems.
The project focuses on memristors based on aromatic aminoacids. The tasks will include performing first principles computations to simulate electronic structure and properties of the functional molecules.
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1
Terms of employment: 1/3 full-time equivalent (or hourly equivalent in the case of a mandate contract) up to 24 months (in 6-month intervals); a monthly salary of approximately PLN 1,800 gross, corresponding to the level of remuneration offered for comparable positions at the Institute of Organic Chemistry PAS in projects funded from external sources.
Benefits (in the case of an employment contract): private medical care package, co-financing for sports activities, co-financing for leisure activities, opportunity to participate in training to improve qualifications
Career development opportunities: work in a dynamically developing team, access to advanced research infrastructure, opportunity to cooperate with foreign research centers, possibility of further career development at IOC PAS, participation in training and scientific conferences.
Project manager: Dr Cina Foroutan-Nejad
e-mail: cina.foroutan-nejad@icho.edu.pl

We are an open and inclusive employer – we encourage applications from all individuals, regardless of gender, origin, nationality, or minority background.

required competencies
desirable competencies
Along with the required documents, please send a scan of a signed consent to the processing of personal data available at: https://www.icho.edu.pl/en/cooperations/career/
The Candidate will be selected on the basis of the submitted application.
15.05.2026, 23:00
20.05.2026
Envisaged job starting date: 25.05.2026
Secretariat
Institute of Organic Chemistry of the Polish Academy of Sciences
Kasprzaka 44/52 Street
01-224 Warsaw
Phone: +48 22 631 8788
Applications must be sent to e-mail address: rekrutacja@icho.edu.pl
ATTENTION! In the title of the e-mail, please enter reference number “CKCOM2026S2”.
“Center for Quantum Digital Organic Memristors”
FENG.02.01-IP.05.-M005/25
The „Center for Quantum Digital Organic Memristors” project is carried out within the International Research Agendas (MAB FENG) programme of the Foundation for Polish Science co-financed by the European Union under the European Funds for Smart Economy 2021-2027 (FENG).
The Center for Quantum Digital Organic Memristors (CKCOM) project focuses on the development of a new generation of molecular memory and logic elements based on proton quantum tunneling. The aim is to advance energy-efficient memcomputing technologies that integrate information processing and storage within single molecular systems, with potential applications in nanoelectronics and AI systems.
The project focuses on memristors based on aromatic aminoacids. The tasks will include: synthesis of intermediates and target functional dyes, purification of products, complete chemical, spectral, and photophysical characterization of the obtained products, collaboration with MSc and PhD students, writing reports and publications.
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1
Terms of employment: Full-time employment for 12 months, with the possibility of extension (no longer than until 31 December 2029); a monthly salary of approximately PLN 11,800 gross, corresponding to the level of remuneration offered for comparable positions at the Institute of Organic Chemistry PAS in projects funded from external sources.
Benefits: private medical care package; co-financing of sports cards
Career development opportunities: Work in an dynamically developing research team; access to advanced research infrastructure; opportunities for collaboration with international research centres; and prospects for further professional development at the Institute of Organic Chemistry PAS, participation in international conferences
Project manager: Dr Marek Grzybowski
Phone: +48 22 3432035
e-mail: marek.grzybowski@icho.edu.pl

We are an open and inclusive employer – we encourage applications from all individuals, regardless of gender, origin, nationality, or minority background.

PhD degree in awarded no more than five years before the application date[1] in chemistry or a submitted doctoral dissertation along with a certificate confirming the scheduled defense date.
[1] The five years is calculated from the year in which the doctoral degree was awarded. The beginning of this period is determined by the calendar year of obtaining the degree, and the end by the year preceding the deadline for submitting applications in the competition. The five-year limit may be extended by any documented interruptions in research activity that occurred after the award of the doctoral degree, provided that each interruption lasted no less than six months. Documented interruptions in research activity include, among others, unpaid leaves, parental leaves, breaks caused by long-term illness, employment in the R&D sector without involvement in scientific research, or employment in other sectors of the economy. For women who have given birth to a child or for individuals who have adopted a child, the five years shall be extended by one year per child, regardless of the date of birth or adoption, even if the documented leave or break related to this event was shorter.
required competencies
desirable competencies
Along with the required documents, please send a scan of a signed consent to the processing of personal data available at: https://www.icho.edu.pl/en/cooperations/career/
15.05.2026, 8:00 PM CEST
29.05.2026
Envisaged job starting date: 01.06.2026
Secretariat
Institute of Organic Chemistry of the Polish Academy of Sciences
Kasprzaka 44/52 Street
01-224 Warsaw
Phone: +48 22 631 8788
Applications must be sent to e-mail address: rekrutacja@icho.edu.pl
ATTENTION! In the title of the e-mail, please enter reference number “CKCOM/2026/MD/7”.
Recruitment results are sent to all candidates by e-mail to the address indicated in the application immediately after the selection process is completed. The ranking list is available from the contact person indicated in the announcement and from the Human Resources Department of the Institute of Organic Chemistry of the PAS.