News

A joint paper by Prof. Jacek Mlynarski and the Chinese research team led by Prof. Xihe Bi has been published in Nature Chemistry, reporting a breakthrough thermal [2+2] cycloaddition that was previously considered as symmetry-forbidden due to ground-state orbital symmetry constraints. The developed methodology enables highly selective access to novel gem-difluorinated bicyclic frameworks of significant relevance to medicinal chemistry. This discovery opens new avenues for constructing complex molecular architectures under non-photochemical conditions.

Y. Ning, R. Wu, Y. Ning, Q. Song, J. Deng, Q. Jiao, P. Sivaguru, J. Mlynarski, G. de Ruiter, X. Hong, X. Bi, „Thermal [2+2] cycloaddition as a route to gem-difluoro heterobicyclo[n.1.1]alkanes”, Nat. Chem.