Head of the group
Prof. Jacek Młynarski

Professors
Prof. Sławomir Jarosz
Assoc. Prof. Zbigniew Pakulski
Assoc. Prof. Zbigniew Kałuża

Adjuncts
Dr Robert Bujok

Assistants
Dr Karol Michalak
Dr Michał Kulczykowski
Dr Anna Osuch-Kwiatkowska

Chemists
Romuald Karczewski

PhD Students
Mgr Robert Pawłowski
Mgr Tomasz Podlewski
Mgr Łukasz Włoszczak
Mgr inż. Joanna Jaszczewska-Adamczak
Mgr Paulina Baczewska

OPUS NCN 2021/41/B/ST4/01617
“Artificial Intelligence meets Asymmetric Catalysis: a new pathway for catalyst optimization and discovery”

Publications

T. Klucznik, L.-D. Syntrivanis, S. Baś, B. Mikulak-Klucznik, M. Moskal, S. Szymkuć, J. Młynarski, L. Gadina, W. Beker, M. D. Burke, K. Tiefenbacher, B. A. Grzybowski, „Computational prediction of complex cationic rearrangement outcomes”, Nature

A. Pieczara, A. Borek-Dorosz, S. Buda, W. Tipping, D. Graham, R. Pawłowski, J. Młynarski, M. Barańska, „Modified glucose as a sensor to track the metabolism of individual living endothelial cells – Observation of the 1602 cm−1 band called “Raman spectroscopic signature of life”” , Biosensors and Bioelectronics

A. Pieczara, E. Matuszyk, P. Szcześniak, J.Młynarski, M. Barańska, „Changes in the mitochondrial membrane potential in endothelial cells can be detected by Raman microscopy”, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

B. Radwan, S. Rocchetti, E. Matuszyk, M. Sternak, M. Stodulski, R. Pawlowski, J. Młynarski, K. Brzozowski, S. Chlopicki, M. Baranska, „EdU sensing: The Raman way of following endothelial cell proliferation in vitro and ex vivo”, Biosensors and Bioelectronics

K. Molga, S. Szymkuć, P. Gołębiowska, O. Popik, P. Dittwald, M. Moskal, R. Roszak, J. Młynarski, B. Grzybowski, „A computer algorithm to discover iterative sequences of organic reactions”Nature Synthesis

R. Pawlowski, M. Stodulski, J. Młynarski, “Propargylation of CoQ0 through the Redox Chain Reaction”, J. Org. Chem.

J. Młynarski, J. A. Jaszczewska-Adamczak, “Asymmetric Epoxidation of Enones Promoted by Dinuclear Magnesium Catalyst”, Adv. Synth. Catal.

R. Campagna, Ł. Mateuszuk, K. Wojnar-Lason, P. Kaczara, A. Tworzydło, A. Kij, R. Bujok, J. Młynarski, Y. Wange, D. Sartini, M. Emanuelli, S. Chlopicki, “Nicotinamide N-methyltransferase in endothelium protects against oxidant stress-induced endothelial injury”BBA – Molecular Cell Research.

E. Matuszyk, A. Adamczyk, B. Radwan, A. Pieczara, P. Szcześniak, J. Młynarski, K. Kamińska, M. Baranska, „Multiplex Raman imaging of organelles in endothelial cells”, Spectrochim. Acta A Mol. Biomol. Spectrosc.

I. Węglarz, K. Michalak, J. Młynarski, „Zinc‐Catalyzed Asymmetric Hydrosilylation of Cyclic Imines: Synthesis of Chiral 2‐Aryl‐Substituted Pyrrolidines as Pharmaceutical Building Blocks”, Adv. Synth. Catal.

B. Mikulak-Klucznik, P. Gołębiowska, A. A. Bayly, O. Popik, T. Klucznik, S. Szymkuć, E. P. Gajewska, P. Dittwald, O. Staszewska-Krajewska, W. Beker, T. Badowski, K. A. Scheidt, K. Molga, J. Młynarski, M. Mrksich, B. A. Grzybowski, „Computational planning of the synthesis of complex natural products”, Nature

M. Pasternak‐Suder, W. Pacułt, S. Baś, J. Młynarski, „Asymmetric Aldol Reaction of Pyruvate Promoted by Chiral Tertiary Amines”, ChemistrySelect

M. Stefaniak, S. Buda, J. Młynarski, „Asymmetric hetero Diels‐Alder reaction of trans‐1‐methoxy‐3‐trimethylsilyloxy‐buta‐1,3‐diene catalyzed by zinc complexes”, Eur. J. Org. Chem.

A. Świerczek, K. Pociecha, M. Ślusarczyk, G. Chłoń-Rzepa, S. Baś, J. Młynarski, K. Więckowski, M. Zadrożna, B. Nowak, E. Wyska, „Comparative Assessment of the New PDE7 Inhibitor – GRMS-55 and Lisofylline in Animal Models of Immune-Related Disorders: A PK/PD Modeling Approach”, Pharm Res

I. Węglarz, M. Szewczyk, J. Młynarski, „Zinc Acetate Catalyzed Enantioselective Reductive Aldol Reaction of Ketones”, Adv. Synth. Catal.

E. P. Gajewska, S. Szymkuć, P. Dittwald, M. Startek, O. Popik, J. Młynarski, B. A. Grzybowski, „Algorithmic Discovery of Tactical Combinations for Advanced Organic Syntheses”, Chem

M. Nawój, A. Grobelny, J. Młynarski, „Macrolide Core Synthesis of Calysolin IX via Intramolecular Glycosylation Approach”, Eur. J. Org. Chem.

A. Adamkiewicz, I. Węglarz, A. Butkiewicz, M. Woyciechowska, J. Młynarski, „Lewis Acid‐Catalyzed Stereoselective α‐Addition of Chiral Aldehydes to Cyclic Dienol Silanes: Aqueous Synthesis of Chiral Butenolides”, Adv. Synth. Catal.

P. Szcześniak, S. Buda, L. Lefevre, O. Staszewska‐Krajewska, J. Młynarski, „Total Asymmetric Synthesis of (+)‐Paroxetine and (+)‐Femoxetine”, Eur. J. Org. Chem.

M. A. Dudek, E. Machalska, T. Oleszkiewicz, E. Grzebelus, R. Barański, P. Szcześniak, J. Młynarski, G. Zając, A. Kaczor, M. Barańska, „Chiral Amplification in Nature: Cell‐extracted Chiral Carotenoid Microcrystals Studied Via RROA of Model Systems”, Angew. Chem. Int. Ed.

P. Szcześniak, O. Staszewska-Krajewska, J. Młynarski, „Total Asymmetric Synthesis of (+)-Asenapine.”, Org. Biomol. Chem.

P. Szcześniak, O. Staszewska-Krajewska, B. Furman, J. Młynarski, „Solid supported Hayashi-Jorgensen Catalyst as an Efficient and Recyclable Catalyst for Asymmetric Michael Addition Reaction”, Tetrahedron: Asymmetry

G. Łopatkiewicz, S. Buda, J. Młynarski, „Application of the EF and GH Fragments to the Synthesis of Idraparinux”, J. Org. Chem.

A. Dudek, J. Młynarski, „Iron-Catalyzed Nitro-Mannich Reaction”, J. Org. Chem.

P. Szcześniak, O. Staszewska-Krajewska, B. Furman, J. Młynarski, „Asymmetric Synthesis of Cyclic Nitrones via Organiocatalytic Michael Addition of Aldehydes to Nitroolefins and Subsequent Reductive Cyclization Chemistry”, Select

P. Konieczny, Ł. Michalski, R. Podgajny, S. Chorazy, R. Pełka, D. Czernia, S. Buda, J. Młynarski, B. Sieklucka, T. Wasiutyński, „Self-Enhancement of Rotating Magnetocaloric Effect in Anisotropic Two-Dimensional (2D) Cyanido-Bridged MnII–NbIV Molecular Ferrimagnet”, Inorg. Chem.

G. Zajac, A. Kaczor, S. Buda, J. Mlynarski, J. Frelek, J. Dobrowolski, M. Baranska, „Prediction of ROA and ECD Related to Conformational Changes of Astaxantin Enantiomers”, J. Phys. Chem. B.

M. Szewczyk, F. Stanek, A. Bezłada, J. Mlynarski, „Zinc Acetate-Catalyzed Highly Enantioselective Hydrosilylation of Ketones”, Adv. Synth. Catal.

M. Rogozińska-Szymczak, J. Mlynarski, „Unmodified Primary Amine Organocatalysts for Asymmetric Michael Reaction in Aqueous Media”, Eur. J. Org. Chem.

S. Chorazy, M. Reczynski, R. Podgajny, W. Nogas, S. Buda, M. Rams, W. Nitek, B. Nowicka, J. Mlynarski, S.-i. Ohkoshi, B. Sieklucka, „Implementation of Chirality into High-Spin Ferromagnetic CoII9WV6 and NiII9WV6 Cyanido-Bridged Clusters”, Cryst. Growth Des.

B. Gut, J. Mlynarski, „Tertiary Amine-Promoted Asymmetric Aldol Reaction of Aldehydes”, Eur. J. Org. Chem.

S.Chorazy, R. Podgajny, W. Nogas, S. Buda, W. Nitek, J. Mlynarski, M. Rams, M. Kozieł, E. Juszyńska-Gałązka, V. Vieru, L. Chibotaru, B. Sieklucka, „Optical Activity and Dehydration-Driven Switching of Magnetic Properties in Enantiopure Cyanido-Bridged CoII3WV2 Trigonal Bipyramids”, Inorg. Chem.

O. Popik, M. Pasternak-Suder, S. Baś, J. Mlynarski, „Organocatalytic Synthesis of Higher-carbon Sugars: Efficient Protocols for the Synthesis of Natural Seduheptulose and D-glycero-L-galacto-oct-2-ulose”, ChemistryOpen. This article is part of the Virtual Special Issue “Carbohydrates in the 21st Century: Synthesis and Applications”.

M. A. Molenda, S. Baś, O. El-Sepelgy, M. Stefaniak, J. Mlynarski, „Chemistry of Pyruvate Enolates: anti-selective Direct Aldol Reaction of Pyruvate Ester with Chiral Aldehydes Promoted by Dinuclear Zinc Catalyst”, Adv. Synth. Catal.

S. Buda, M. Nawój, P. Gołębiowska, K. Dyduch, A. Michalak, J. Mlynarski, „Application of 2-Substituted Benzyl Groups in Stereoselective Glycosylation”, J. Org. Chem.

D. Łowicki, S. Baś, J. Mlynarski, „Chiral Zinc Catalysts for Asymmetric Synthesis”, Tetrahedron

Research topics

  • asymmetric catalysis with zinc- and magnesium chiral Lewis acids
  • new pathway to catalyst discovery by using Artificial Intelligence
  • asymmetric reduction of prochiral ketones and imines promoted by zinc complexes
  • stereocontrolled synthesis of natural and bioactive products
  • direct aldol reaction of hydroxyacetone and dihydroxyacetone
  • light-induced transformations