Head of the group
Prof. Jacek Młynarski

Assistants
Dr Robert Bujok
Dr Karol Michalak
Dr Oskar Popik

PhD Students
Mgr Robert Pawłowski
Mgr Tomasz Podlewski
Mgr Łukasz Włoszczak
Mgr inż. Joanna Jaszczewska-Adamczak

TEAM FNP – (2017-4/38) New organocatalytic strategies: towards drugs and bioactive compounds

OPUS NCN – ( 2017/27/B/ST5/01111 ) Zinc instead of noble metals: enantioselective reduction and carbon-carbon bond forming reactions promoted by zinc complexes

Diamentowy Grant – Robert Pawłowski – ( DI2017 001947 ) Badania tandemowych procesów organo- i fotokatalitycznych

Publications

J. Mlynarski, J. A. Jaszczewska-Adamczak, “Asymmetric Epoxidation of Enones Promoted by Dinuclear Magnesium Catalyst”, Adv. Synth. Catal.

R. Campagna, Ł. Mateuszuk, K. Wojnar-Lason, P. Kaczara, A. Tworzydło, A. Kij, R. Bujok, J. Mlynarski, Y. Wange, D. Sartini, M. Emanuelli, S. Chlopicki, “Nicotinamide N-methyltransferase in endothelium protects against oxidant stress-induced endothelial injury”,  BBA – Molecular Cell Research.

E. Matuszyk, A. Adamczyk, B. Radwan, A. Pieczara, P. Szcześniak, J. Mlynarski, K. Kamińska, M. Baranska, „Multiplex Raman imaging of organelles in endothelial cells”, Spectrochim. Acta A Mol. Biomol. Spectrosc.

I. Węglarz, K. Michalak, J. Mlynarski, „Zinc‐Catalyzed Asymmetric Hydrosilylation of Cyclic Imines: Synthesis of Chiral 2‐Aryl‐Substituted Pyrrolidines as Pharmaceutical Building Blocks”, Adv. Synth. Catal.

K. Michalak, L. Rárová, M. Kubala, T. Štenclová, M. Strnad, J. Wicha, „Synthesis and evaluation of Na+/K+-ATP-ase inhibiting and cytotoxic in vitro activities of oleandrigenin and its selected 17β-(butenolidyl)- and 17β-(3-furyl)- analogues”, Eur. J. Med. Chem.

R. Pawłowski, P. Skorka, M. Stodulski, „Radical‐Mediated Non‐Dearomative Strategies in Construction of Spiro Compounds”, Adv. Synth. Catal.

P. Popik, S. Yon-Seng Khoo, A. Kuziak, J. Golebiowska, A. Potasiewicz, A. Hogendorf, O. Popik, M. Matloka, R. Moszczynski, A. Nikiforuk, J. M. Witkin, „Distinct cognitive and discriminative stimulus effects of ketamine enantiomers in rats”, Pharmacol. Biochem. Behav.

B. Mikulak-Klucznik, P. Gołębiowska, A. A. Bayly, O. Popik, T. Klucznik, S. Szymkuć, E. P. Gajewska, P. Dittwald, O. Staszewska-Krajewska, W. Beker, T. Badowski, K. A. Scheidt, K. Molga, J. Młynarski, M. Mrksich, B. A. Grzybowski, „Computational planning of the synthesis of complex natural products”, Nature

M. Pasternak‐Suder, W. Pacułt, S. Baś, J. Mlynarski, „Asymmetric Aldol Reaction of Pyruvate Promoted by Chiral Tertiary Amines”, ChemistrySelect

F. Stanek, R. Pawłowski, P. Morawska, R. Bujok, M. Stodulski, „Dehydrogenation and α-functionalization of secondary amines by visible-light-mediated catalysis”, Org. Biomol. Chem.

M. Stefaniak, S. Buda, J. Mlynarski, „Asymmetric hetero Diels‐Alder reaction of trans‐1‐methoxy‐3‐trimethylsilyloxy‐buta‐1,3‐diene catalyzed by zinc complexes”, Eur. J. Org. Chem.

A. Świerczek, K. Pociecha, M. Ślusarczyk, G. Chłoń-Rzepa, S. Baś, J. Mlynarski, K. Więckowski, M. Zadrożna, B. Nowak, E. Wyska, „Comparative Assessment of the New PDE7 Inhibitor – GRMS-55 and Lisofylline in Animal Models of Immune-Related Disorders: A PK/PD Modeling Approach”, Pharm Res

I. Węglarz, M. Szewczyk, J. Młynarski, „Zinc Acetate Catalyzed Enantioselective Reductive Aldol Reaction of Ketones”, Adv. Synth. Catal.

E. P.Gajewska, S. Szymkuć, P. Dittwald, M. Startek, O. Popik, J. Mlynarski, B. A. Grzybowski, „Algorithmic Discovery of Tactical Combinations for Advanced Organic Syntheses”, Chem

M. Nawój, A. Grobelny, J. Mlynarski, „Macrolide Core Synthesis of Calysolin IX via Intramolecular Glycosylation Approach”, Eur. J. Org. Chem.

A. Adamkiewicz, I. Węglarz, A. Butkiewicz, M. Woyciechowska, J. Młynarski, „Lewis Acid‐Catalyzed Stereoselective α‐Addition of Chiral Aldehydes to Cyclic Dienol Silanes: Aqueous Synthesis of Chiral Butenolides”, Adv. Synth. Catal.

R. Rusiecki, J. Witkowski, J. Jaszczewska-Adamczak, „MDM2-p53 Interaction Inhibitors: The Current State-of-Art and Updated Patent Review (2010-Present)”, Recent Pat. Anticancer Drug Discov.

P. Szcześniak, S. Buda, L. Lefevre, O. Staszewska‐Krajewska, J. Mlynarski, „Total Asymmetric Synthesis of (+)‐Paroxetine and (+)‐Femoxetine”, Eur. J. Org. Chem.

K. Michalak, L. Rárová, M. Kubala, P. Čechová, M. Strnad, J. Wicha, „Synthesis and evaluation of cytotoxic and Na+/K+-ATP-ase inhibitory activity of selected 5α-oleandrigenin derivatives”, Eur. J. Med. Chem.

R. Pawlowski, F. Stanek, M. Stodulski, „Recent Advances on Metal-Free, Visible-Light- Induced Catalysis for Assembling Nitrogen- and Oxygen-Based Heterocyclic Scaffolds”, Molecules

M. A. Dudek, E. Machalska, T. Oleszkiewicz, E. Grzebelus, R. Baranski, P. Szcześniak, J. Mlynarski, G. Zajac, A. Kaczor, M. Baranska, „Chiral Amplification in Nature: Cell‐extracted Chiral Carotenoid Microcrystals Studied Via RROA of Model Systems”, Angew. Chem. Int. Ed.

P. Szcześniak, O. Staszewska-Krajewska, J. Mlynarski, „Total Asymmetric Synthesis of (+)-Asenapine.”, Org. Biomol. Chem.

P. Szcześniak, O. Staszewska-Krajewska, B. Furman, J. Mlynarski, „Solid supported Hayashi-Jorgensen Catalyst as an Efficient and Recyclable Catalyst for Asymmetric Michael Addition Reaction”, Tetrahedron: Asymmetry

G. Łopatkiewicz, S. Buda, J. Mlynarski, „Application of the EF and GH Fragments to the Synthesis of Idraparinux”, J. Org. Chem.

A. Dudek, J. Mlynarski, „Iron-Catalyzed Nitro-Mannich Reaction”, J. Org. Chem.

P. Szcześniak, O. Staszewska-Krajewska, B. Furman, J. Mlynarski, „Asymmetric Synthesis of Cyclic Nitrones via Organiocatalytic Michael Addition of Aldehydes to Nitroolefins and Subsequent Reductive Cyclization Chemistry”, Select

P. Konieczny, Ł. Michalski, R. Podgajny, S. Chorazy, R. Pełka, D. Czernia, S. Buda, J. Mlynarski, B. Sieklucka, T. Wasiutyński, „Self-Enhancement of Rotating Magnetocaloric Effect in Anisotropic Two-Dimensional (2D) Cyanido-Bridged MnII–NbIV Molecular Ferrimagnet”, Inorg. Chem.

G. Zajac, A. Kaczor, S. Buda, J. Mlynarski, J. Frelek, J. Dobrowolski, M. Baranska, „Prediction of ROA and ECD Related to Conformational Changes of Astaxantin Enantiomers”, J. Phys. Chem. B.

M. Szewczyk, F. Stanek, A. Bezłada, J. Mlynarski, „Zinc Acetate-Catalyzed Highly Enantioselective Hydrosilylation of Ketones”, Adv. Synth. Catal.

M. Rogozińska-Szymczak, J. Mlynarski, „Unmodified Primary Amine Organocatalysts for Asymmetric Michael Reaction in Aqueous Media”, Eur. J. Org. Chem.

S. Chorazy, M. Reczynski, R. Podgajny, W. Nogas, S. Buda, M. Rams, W. Nitek, B. Nowicka, J. Mlynarski, S.-i. Ohkoshi, B. Sieklucka, „Implementation of Chirality into High-Spin Ferromagnetic CoII9WV6 and NiII9WV6 Cyanido-Bridged Clusters”, Cryst. Growth Des.

B. Gut, J. Mlynarski, „Tertiary Amine-Promoted Asymmetric Aldol Reaction of Aldehydes”, Eur. J. Org. Chem.

S.Chorazy, R. Podgajny, W. Nogas, S. Buda, W. Nitek, J. Mlynarski, M. Rams, M. Kozieł, E. Juszyńska-Gałązka, V. Vieru, L. Chibotaru, B. Sieklucka, „Optical Activity and Dehydration-Driven Switching of Magnetic Properties in Enantiopure Cyanido-Bridged CoII3WV2 Trigonal Bipyramids”, Inorg. Chem.

O. Popik, M. Pasternak-Suder, S. Baś, J. Mlynarski, „Organocatalytic Synthesis of Higher-carbon Sugars: Efficient Protocols for the Synthesis of Natural Seduheptulose and D-glycero-L-galacto-oct-2-ulose”, ChemistryOpen. This article is part of the Virtual Special Issue “Carbohydrates in the 21st Century: Synthesis and Applications”.

M. A. Molenda, S. Baś, O. El-Sepelgy, M. Stefaniak, J. Mlynarski, „Chemistry of Pyruvate Enolates: anti-selective Direct Aldol Reaction of Pyruvate Ester with Chiral Aldehydes Promoted by Dinuclear Zinc Catalyst”, Adv. Synth. Catal.

S. Buda, M. Nawój, P. Gołębiowska, K. Dyduch, A. Michalak, J. Mlynarski, „Application of 2-Substituted Benzyl Groups in Stereoselective Glycosylation”, J. Org. Chem.

D. Łowicki, S. Baś, J. Mlynarski, „Chiral Zinc Catalysts for Asymmetric Synthesis”, Tetrahedron

Research topics

  • asymmetric catalysis with zinc- and magnesium chiral Lewis acids
  • new pathway to catalyst discovery by using Artificial Intelligence
  • asymmetric reduction of prochiral ketones and imines promoted by zinc complexes
  • stereocontrolled synthesis of natural and bioactive products
  • direct aldol reaction of hydroxyacetone and dihydroxyacetone
  • light-induced transformations