Group VII. 
Chemical Synthesis and Technology of Antibiotics

Staff:

Robert Bujok Ph.D.; Cezary Gulko, techn.; Katarzyna Gwardiak, techn.; Romuald Karczewski, techn.; Anna Korda, Ph.D.; Andrzej Kwast, Ph.D; Andrzej Zarecki Ph.D.

Research activity:

The group offers a custom synthesis service for organic compounds. Specialization – organic synthesis depending on current needs and orders. Experience in:

·         Classical synthesis

·         Synthesis and technology of b-lactam antibiotics

·         Peptide synthesis

·         Chemical synthesis and technology of b-lactam and quinolone antibiotics

·         Application of the new synthetic methods for industrial purposes: development of technology and upscaling. Application of analytical methods for process control

·         Synthesis of analytical standards of drug active substances and standards of their impurities together with development of analytical methods for their determination

The research activity depends on present orders.

Constant interest focused on the synthesis of nitrogen heterocycles from nitroarenes.

Selected scientific publications:

1.    Wróbel, Z. “Double Thioalkylation/arylation of Nitroarenes with the Reduction of Nitro- to Amino- group” Tetrahedron 2003, 59, 101-110

2.    Korda, A.; Wróbel, Z. „A New Way to 2-Methylbenzo- and Pyridoindoles” Synlett, 2003, 1465-1466

3.    Wróbel, Z. “A simple Way to Some Sophisticated Fused Nitrogen Heterocycles” Synlett 2004, 1929-1932

4.    Korda, A.; Wróbel, Z. Gwardiak, K. „An Efficient Route from Trifluoroacetates to Water Soluble Free Amines Using Diaionâ HP-20” Amino Acids 2005, 95-98

5.    Wróbel, Z.; Bobin, M.; Karczewski, R. „N-Substituted 5-Aryl-1,3-oxazolidin-2-ones from Arylethylene Oxides” Pol. J. Chem. 2006, 80, 907-912

6.   Wróbel, Z.; Kwast A. „Nucleophilis Substitution of Halogen with Amines in 2- and 4-Nirtophenols” Synthesis 2007, 259-262