Group
VI
ASYMMETRIC CATALYSIS: APPLICATION OF CHIRAL LEWIS AND BRØNSTED ACIDS
|
Head of the group: Assoc. Prof. Jacek Młynarski e-mail: <mlynar@icho.edu.pl> |
Ph.D., Institute of Organic Chemistry Polish Academy of Sciences, Warsaw, Poland, 2000 Foundation for Polish Science Fellowship, 2000 Prime Minister of Polish Government Prize, 2001 Post-doc, MPI, Mülheim a.d. Ruhr, Germany, 2001-2002 (Prof. Alois Fürstner) Alexander von Humboldt Fellowship, 2001 Habilitation, Institute of Organic Chemistry Polish Academy of Sciences, Warsaw, Poland, 2006 Polish Academy of Sciences Włodzimierz Kołos Prize, 2007 |
Homepage of the group: http://jacekmlynarski.pl
Staff:
Maciej Stodulski Ph.D. Student, Joanna Paradowska Ph.D. Student, Agnieszka Mamińska M.Sc. Student, Maria Rogozińska M.Sc. Student
Research activity
Research in our group is focused on organic synthesis and the discovery of new reaction methodology, in particular stereoselective and catalytic asymmetric reactions. Our current research interest involves enantioselective synthetic methodology rely on metal-based chiral catalysts. The following topics are recently being studied in our laboratories:
1. Tandem asymmetric aldol reaction/reduction leading stereoselectively to anti-1,3-diols.
2. Development of water-compatible chiral Lewis acids.
3. Designing of new catalysts for direct asymmetric aldol and aldol-type reactions in water.
4. Synthesis of novel pybox-type ligands for asymmetric aqua-Mukaiyama reaction (designing of water-compatible chiral Zn and Fe complexes).
5. Towards enzyme mimics: direct aldol reaction in water promoted by chiral Zn(II) complexes as well as small organic molecules.
Selected scientific publications:
1. Paradowska,
J.; Stodulski, M.; Mlynarski, J.:
Direct Catalytic Asymmetric
Aldol Reactions Assisted by Zinc Complex in the Presence of Water
Adv. Synth. Catal.
2007,
239, 1041-1046
2.
Jankowska J.; Paradowska, J.;
Rakiel, B.; Mlynarski, J.: Iron(II) and Zinc(II) Complexes with
Designed pybox Ligands for the Asymmetric Aqueous Mukaiyama-Aldol
Reactions
J. Org.
Chem. 2007,
72, 2228-2231
3. Mlynarski,
J.: Direct Asymmetric Aldol-Tishchenko Reaction Microreview
Eur. J. Org. Chem. 2006, 4779-4786
4. Mlynarski,
J., Rakiel B.; Stodulski, M.; Suszczyńska, A., Frelek, J.: The Chiral
Ytterbium Complexes-Catalyzed Direct Asymmetric Aldol-Tishchenko Reaction.
Synthesis of anti-1,3-Diols
Chem. Eur. J. 2006, 12, 8158-8167
5. Jankowska
J.; Paradowska, J.; Mlynarski, J.:
A Chiral Iron(II)–Pybox Catalyst Stable
in Aqueous Media. Asymmetric Mukaiyama–Aldol Reaction
Tetrahedron Lett. 2006, 47, 5281-5284
6. Jankowska,
J.; Mlynarski, J.: Zn(pybox)-Complex Catalyzed Asymmetric Aqueous
Mukaiyama-Aldol Reactions
J. Org. Chem. 2006, 71, 1317-1321
7. Mlynarski,
J.; Jankowska J.; Rakiel, B.: Direct Asymmetric Aldol-Tishchenko
Reaction of Aliphatic Ketones Catalyzed by
syn-Aminoalcohol-Yb(III)-Complexes
Chem. Commun. 2005, 4854-4856
8. Mlynarski,
J.; Jankowska, J.; Rakiel, B.: Synthesis of Chiral Hybrid O,N-Donor
Ligands for the Investigation of Lanthanide Complex Reactivity in Direct
Aldol Condensation
Tetrahedron: Asymmetry 2005, 8, 1521-1526
9. Mlynarski,
J.; Jankowska, J.: Asymmetric Mukaiyama-Aldol Reaction in Aqueous Media
Promoted by Zinc-Based Chiral Lewis Acids
Adv. Synth. Catal. 2005, 347, 521-525
10. Mlynarski,
J.; Mitura, M.: The First Example of Aldol-Tishchenko Reaction of
Aldehydes and Aliphatic Ketones
Tetrahedron Lett. 2004, 45, 7549-7552
