Group
III.
Organometallic Chemistry Applied to Organic Synthesis
|
Head of the group: Prof. Karol Grela
e-mail: <grela@icho.edu.pl>
Research Profile:
http://www.researcherid.com/rid/ |
Ph.D., Institute of Organic Chemistry Polish Academy of Sciences, Warsaw, Poland, 1998 Post-doc, MPI, Mülheim a.d. Ruhr, Germany, 1999-2000 Habilitation, Institute of Organic Chemistry Polish Academy of Sciences, Warsaw, Poland, 2003 Full Professor, 2008 Foundation for Polish Science Fellowship, 1998 Prime Minister of Polish Government Prize, 1999 and 2004 Alexander von Humboldt Fellowship, 1999 Polish Academy of Sciences Włodzimierz Kołos Prize, 2003 Foundation for Polish Science “Mistrz” Professorship, 2007 Maria Skłodowska-Curie and Wilhelm Klemm Lectureship <http://www.gdch.de/gdch/eps/namen/curie.htm> Award of the German and the Polish Chemical Society, 2007 Polish delegate to the EuCheMS Division of Organometallic Chemistry |
Staff:
Andrzej Zarecki, Ph.D.; Anna Szadkowska, Ph.D. student; Jak Klajn, Ph.D. student; Cezary Samojłowicz, Ph.D. student; Rafał Gawin, Ph.D. student; Daniel Burtscher, postdoc
Research activities:
Our research is mainly concerned with the development and improvement of organometallic reactions as well as their application to the synthesis of natural products and pharmaceutically relevant compounds. Current research is mainly focused on stereoselective organic synthesis mediated by transition metals with special emphasis on alkyne and alkene metathesis. Areas of
investigation encompass the design of new user-friendly, supported or recyclable stable metathesis catalysts and extending the scope of the reaction itself.
Selected scientific publications (number of papers published: over 60):
1. Gułajski, Ł.; Sledź, P.; Lupa, A.; Grela, K.; "Olefin metathesis in water using acoustic emulsification" Green Chem. 2008, 10, 279-282
2. Gułajski, Ł.; Michrowska, A.; Narożnik, J.; Kaczmarska, Z.; Rupnicki, L.; Grela, K. "A Highly Active Aqueous Olefin Metathesis Catalyst Bearing a Quaternary Ammonium Group" ChemSusChem 2008, 1, 103-109
3. Gawin, R.; Makal, A.; Woźniak, K.; Mauduit, M.; Grela, K. "Dormant Ruthenium Catalyst Bearing Chelating Carboxylate Ligand: In Situ Activation and Application in Metathesis Reactions " Angew. Chem. Int. Ed. 2007, 46, 7206-7209
4. Clavier, H.; Grela, K.; Kirschning, A.; Mauduit, M.; Nolan, S. P. "Sustainable Concepts in Olefin Metathesis" Angew. Chem. Int. Ed. 2007, 46, 6786-6801
5. Bieniek, M.; Bujok, R.; Cabaj, M.; Lugan, N.; Lavigne, G.; Arlt, D.; Grela, K.; "Advanced fine tuning of Grubbs/Hoveyda olefin metathesis catalysts: a further step toward an optimum balance between antinomic properties" J. Am. Chem. Soc. 2006, 128, 13652-13653
6. Michrowska, A.; Mennecke, K.; Kunz, U.; Kirschning, A.; Grela, K.; "A New Concept for the Non Covalent Binding of a Ruthenium-based Olefin Metathesis Catalyst to Polymeric Phases: Preparation of a Catalyst on Raschig Rings" J. Am. Chem. Soc. 2006, 128, 13261-13267
7. Michrowska, A.; Bujok, R.; Harutyunyan, S.; Sashuk, V.; Dolgonos, G.; Grela, K. "Nitro-Substituted Hoveyda-Grubbs Ruthenium Carbenes: Enhancement of Catalysts Activity through Electronic Activation" J. Am. Chem. Soc. 2004, 126, 9318-9325
8. Grela, K.; Harutyunyan; S., Michrowska, A. "A New Highly Efficient Ruthenium Catalyst for Metathesis Reaction" Angew. Chem. Int. Ed. 2002, 41, 4038-4040
