Group XX. Enzymes and Microorganisms in Organic Synthesis and Biotechnology
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Head of the group Assoc. Prof. Ryszard Ostaszewski e-mail: <rysza@icho.edu.pl> |
M. Sc., 1984, Faculty of Chemistry, Warsaw Technical University (Politechnika), Warszawa, Poland. Ph.D., 1989, Institute of Organic Chemistry PAS. Post-doc, 1989/1990, Postdoctoral fellow with Professor D. N. Reinhoudt University of Twente, the Netherlands, Post-doc, 1994/1995, ETH Postdoctoral fellow with Professor. H.-J. Hansen at University of Zurich, Switzerland, Habilitation, 1999, Institute of Organic Chemistry PAS, Associate Professor 2003, Institute of Organic Chemistry PAS, Award for Young Scientists of the Polish Chemical Society, 1989; |
Staff:
Stanisław Berłożecki, Ph.D..; Waldemar Kurek, Ph.D. student; Marta Komar, Ph.D. student; Dominik Koszelewski, Ph.D. student; Wiktor Ignacak, techn.; Danuta Uliasz, techn.
Research activity
The major research interest of the group is directed towards application of enzymes and microorganisms in organic synthesis and biotechnology. Current interest include application of enzymatic procedure for synthesis of chiral peptidomimetics. For the synthesis of target compounds multicomponent reaction were used. Enzymes required for these studies were prepared using standard procedures. Special attention has beed devoted towards chemical functionalization of enzymes. In many cases, modification of enzymes led to substantial increase of enzymes reactivity and/or stability. Functionalization of enzymes alters their chemical reactivity, what resulted in new type of catalysts.
Research activity of the team is also related to R & D programs for pharmaceutical industry.
Selected scientific publications:
1. R Ostaszewski, A. Bożek, M Pałys, Z. Stojek; Supramol. Chem., 12, 105 (2000), “Investigation of Complexation of Sodium Cation by Anthracene Crown Ethers”.
2. R. Ostaszewski, A. M. Kłonkowski, K. Kledzik; Supramol. Chem., 12, 131, (2000), “A New Fluorescent Chemosensor for Cu2+ Based on Diantharcene-derivative”.
3. R. Pajewski, R. Ostaszewski, J. Jurczak, Supramol. Chem., 12, 97, (2000), “The Reaction of 2,5-bis(dimethylfurfuryl)furane dialdehyde with primary a,w-diamines”.
4. A. M. Kłonkowski, K. Kledzik and R. Ostaszewski, Proc. SPIE, 4516, 44, (2001),
"A chemical Recognition Phase of the Fluorescence Chemical Sensor for Cu(II) Ions in Aqueous Solution".
5. M. Wolszczak, D. Grylik, E. Grzesiak, D. Kowalczyk, K. Sulak, R. Ostaszewski: Ann. Pol. Chem. Soc., 1, 268, (2001), “The intercation of new derivatives of anthracene with calf thymus DNA: photochemical and pulse radiolysis studies”.
6. A. M. Kłonkowski, K. Kledzik, R. Ostaszewski, Frontiers in Biochemical Sensing in XXI Century, Lecture Notes of the ICB Seminars, Warsaw, p. 166 – 167, April 2001, “Chemical Recognition Phase Consisting of a Fluorosensor Immobilised in Silica Xerogel”.
7. M. Wolszczak, E. Grzesiak, D. Kowalska, R. Ostaszewski: Proc. SPIE, 4749, 259, (2002), „Intercation of new derivatives of anthracene with calf thymus DNA”.
8. P. Ćwierzyński, R. Ostaszewski, J. Jurczak: Org. Prep. Proc. Int., 34, 204, (2002), “A general synthesis of macrocyclic esters”.
9. A. M. Kłonkowski, K. Kledzik, R. Ostaszewski, T. Widernik: Colloid Surface A, 208, 115, (2002), "Optical Properties of bis-9-Anthryl Derivatives Immobilised in Silica Xerogel".
10. A. M. Kłonkowski, K. Kledzik, R. Ostaszewski, J. Jezierska, Appl. Surf. Sci., 196, 383, (2002), “Fluorosensor action of bis-9-anthryl derivatives immobilised in silica xerogel”
11. D. E. Portlock, R. Ostaszewski, D. Naskar, L. West; Tetrahedron Lett., 44, 603, (2003), "A Tandem Petasis-Ugi Multi Component Condensation Reaction: Solution Phase Synthesis Of Six Dimensional Libraries"
12. R. Ostaszewski, D. E. Portlock, A. Fryszkowska, K. Jeziorska; Pure Appl. Chem., 75, 413, (2003), “Combination of Enzymatic Procedures with Multi-Component Condensations”.
13. D. E. Portlock, D. Naskar, L. West, R. Ostaszewski, J. Chen, Tetrahedron Lett., 44, 5121 (2003), "Solid-Phase Synthesis of Five-Dimensional Libraries via a Tandem Petasis-Ugi Multi Component Condensation Reaction "
14. K. Jeziorska, R. Ostaszewski, Annals of the Polish Chemical Society, 2, 36, (2003), “A New Approach to the Synthesis of Chiral Peptydomimetics Based on Combination of Passerini and Enzymatic reactions”.
15. K. Jeziorska, A. Fryszkowska, W. Kurek, R. Ostaszewski; Annals of the Polish Chemical Society , 2, 56, (2003), “A new Method for the Synthesis of Peptydomimetics Based on Combination of Enzymatic and Multicomponent Reactions”.
